Assay Guidance Manual for Drug Discovery: Robust or Go Bust
Sarine Markossian, Nathan P. Coussens, Jayme L. Dahlin, Gurusingham Sitta Sittampalam · SLAS DISCOVERY · 2021
There have been considerable efforts in the last two decades within the biomedical science community to address the crisis of irreproducibility in basic and preclinical research.1 Robust assays, with rigorous data analysis reporting standards, help to prevent irreproducibility. Every successful drug discovery campaign begins with the right assay—an assay that measures a biological process in a physiologically relevant and robust manner. Although assays vary substantially with respect to design, speed, throughput, and complexity, they must be robust for an effective drug discovery campaign.