Towards computationally efficient prediction of molecular signatures from routine histology images
Maxime W Lafarge, Viktor H Koelzer · The Lancet Digital Health · 2021
Identification of actionable genomic alterations in diagnostic tissue samples provides key information for personalised cancer treatment. However, current diagnostic tests used to predict the status of molecular pathways from standard histopathology material are commonly tissue destructive, generate relevant costs, and can take hours or even days to return conclusive results. Relating molecular alterations to digital image information derived from standard haematoxylin and eosin-stained histopathology slides has become a task that machine learning models are able to solve across multiple cancer types (appendix).