Repurposing an Antiviral Drug against SARS‐CoV‐2 Main Protease
Arighna Sarkar, Kalyaneswar Mandal · Angewandte Chemie International Edition · 2021
This article highlights recent pioneering work by Günther et al. towards the discovery of potential repurposed antiviral compounds (peptidomimetic and non-peptidic) against the SARS-CoV-2 main protease (Mpro). The antiviral activity of the most potent drugs is discussed along with their binding mode to Mpro as observed through X-ray crystallographic screening.