An optimization-based model discrimination framework for selecting an appropriate reaction kinetic model structure during early phase pharmaceutical process development
Maitraye Sen, Alonso J. Argüelles, Stephen Dion Stamatis, Salvador García‐Muñoz, Stanley P. Kolis · Reaction Chemistry & Engineering · 2021
A model discrimination workflow to develop fit for purpose kinetic models of new pharmaceutical compounds in early stages of drug development involving complex reaction networks with limited prior information and provision to run new experiments.