Detectable Effect Cluster Analysis: A Novel Machine Learning Subgroup Analysis Method for Drug Rescue
Albert A. Taylor, Danielle Beaulieu, Jonabvelle Cuerdo, Mark Schactman, Dustin Pierce, Mike Keymer, David L. Ennist · 2020
ALS drug development has been plagued by high clinical trial failure rates Subgroup analysis is a key tool used to account for patient heterogeneity, but current methods fall short DEC analysis systematically groups and analyzes patients based on predicted disease path, creating more homogeneous patient . subgroups with reduced noise around the endpoint.