Determination of Pravastatin in Drug Formulation by Square-wave Voltammetry on a Glassy Carbon Electrode
Pınar Talay Pınar, Zühre Şentürk, Tamer Tuluk · Van Yüzüncü Yıl University Academic Data Management System · 2019
The electrochemical behavior of Pravastatin, a lipid-lowering drug, on a glassy carbon electrode was explored in Britton-Robinson buffer by using cyclic and square-wave voltammetry. Cyclic voltammetric studies indicated that the compound underwent irreversible oxidation, which was a diffusion-controlled process. Using square-wave voltammetry, Pravastatin could be determined at +1.24 V (vs. Ag/AgCl) in the concentration range 2.4×10 -7 -2.8×10 -6 M at pH 2.0, with a detection limit of 5.0×10 -8 M. The suggested method was successfully applied for the assay of Pravastatin in tablets.