A review of the structure-activity relationships (SAR) of selected drugs with potential to be repurposed against SARS-COV-2
Ukpe Ajima, Jacob Adegboyega Kolawole, Kakjing Dadul Falang, Bukata Bayero Bukar, Kennedy Iliya Amagon, James Garba Damen, Yusuf Amuda Agabi, Richard Joseph Kutshik, Ishaya Yohanna Longdet, Simji Samuel Gomerep, Ismaila Ademola Shittu, Stephen D. D · Asian Journal of Pharmacy and Pharmacology · 2021
Background: The pandemic caused by the novel SARS-CoV-2 virus has escalated rapidly and impacted human health worldwide, in addition to causing severe disruptions to socioeconomic life.There is presently no effective treatment for the disease and this underscores the urgent need for new therapeutic options against this life threatening disease.The traditional strategy for the development of new drugs is a slow and expensive process.Drug repurposing is a valuable alternative strategy that can be used to bypass some of the limitations of traditional drug discovery in order to rapidly develop new therapeutic agents for the management of Covid-19.The present review x-rays recent efforts to re-purpose some antiviral drugs for the treatment Objectives: of SARS-Cov-2 with an emphasis on the structure activity relationships (SAR) of the compounds.A systematic internet Methods: search of three academic databases of published literature was undertaken using relevant keywords and search terms which focused on drug re-purposing against SARS-CoV-2.A total of 853 results were generated and evaluated.The results of the search Results: were screened and relevant articles identified, yielding a total of 83 articles.Some of the drugs identified with potential for repurposing against SARS-CoV-2 include: Arbidol, Favipiravir, Ribavirin, Nitazoxanide etc.It is hoped that the Conclusion: information generated in this review will help deepen understanding of the potential mechanism of anti-SARS-CoV-2 action of the compounds and also draw attention to opportunities that exist for structural modification of these molecules with the aim of improving and enhancing their selectivity and efficacy against SARS-CoV-2.