Structural Genomics-A Goldmine of Blueprints for Structure-Based Drug Design
Garry W. Buchko · Journal of Postgenomics Drug & Biomarker Development · 2011
Multidrug resistant bacterial pathogens pose a serious threat to modern medicine, threatening to make some common medical procedures obsolete [1] and the treatment of some common bacterial infections difficult [2].For example, while effective public health care systems in the Western world keep Mycobacterium tuberculosis, the aetiological agent responsible for tuberculosis, under control, the evolution of multidrug and extremely drug resistant strains of M. tuberculosis may result in the sudden loss of this control [3].Consequently, it is of fundamental importance to develop a new generation of intervention strategies against bacterial pathogens.