Newly synthesized Mpro inhibitors as potential oral anti-SARS-CoV-2 agents
Lin Li, Shile Huang · Signal Transduction and Targeted Therapy · 2021
In a recent paper published in Science , Qiao et al. 1 described the design, synthesis, and characterization of 32 new SARS-CoV-2 M pro inhibitors. SARS-CoV-2 M pro inhibitors have been reported, 2 but there is no infection data in any animal models. For the first time, Qiao et al. 1 demonstrated that oral or intraperitoneal treatment with two compounds (MI-09 and MI-30) exhibits effective antiviral activity in a SARS-CoV-2 infection transgenic mouse model.