Construction of biologically-interpretable chemical–disease association focused on transcription factors organizing chemically-perturbed genes
Zhaonan Zou, M Iwata, Yoshihiro Yamanishi, Shinya Oki · Proceedings for Annual Meeting of The Japanese Pharmacological Society · 2021
Modification of disease-elicited gene expression is one of the core aspects in numerous drugs’ modes of action. To predict drug–disease associations, transcriptomics-based approaches with pathway analysis, graph theory and supervised machine learning-based calculation were developed. However, the pharmacological mechanism employed by drugs remain largely unknown.