Assessment of the rules related to gaining activity against Gram-negative bacteria
Henni‐Karoliina Ropponen, Eleonora Diamanti, Alexandra Siemens, Boris A. Illarionov, Jörg Haupenthal, Markus J. Fischer, Matthias Rottmann, Matthias Christian Witschel, Anna K. H. Hirsch · RSC Medicinal Chemistry · 2021
mutants with respect to the known rules related to enhanced activity against Gram-negative bacteria revealed that applicability of the rules is not always ensured. Out of the four amino acids used in this study, glycine derivatives showed highest antibacterial activity, although still suffering from efflux issues.