Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2
Chih‐Jung Kuo, Tai‐Ling Chao, Han‐Chieh Kao, Ya‐Min Tsai, Yi‐Kai Liu, Lily Hui-Ching Wang, Ming‐Chang Hsieh, Sui‐Yuan Chang, Po‐Huang Liang · Antimicrobial Agents and Chemotherapy · 2021
Coronavirus (CoV) disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed many lives worldwide and is still spreading since December 2019. The 3C-like protease (3CL pro ) and papain-like protease (PL pro ) are essential for maturation of viral polyproteins in SARS-CoV-2 life cycle and thus regarded as key drug targets for the disease.