A comparison of two methods to establish drug-reaction relationships in the ADRAC database
Musa A. Mammadov, Gary Ian Saunders · FedUni ResearchOnline (Federation University Australia) · 2004
Adverse drug reactions (ADRs) are estimated to be one of the leading causes of death. Many national and international agencies have set up databases of ADR reports for the express purpose of determining the relationship between drugs and adverse reactions that they cause. We formulate the drug-reaction relationship problem as a continuous optimization problem and utilize C-GRASP, a new continuous global optimization heuristic, to approximately determine the relationship between drugs and adverse reactions. Our approach is compared against others in the literature and is shown to find better solutions. 1.