Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.
Shao‐Chun Wang, Yeh Chen, Yuchuan Wang, Wei‐Jan Wang, Chia‐Shin Yang, Chia-Ling Tsai, Mei‐Hui Hou, Hsiao‐Fan Chen, Yi-Chun Shen, Mien‐Chie Hung · PubMed · 2020
protein. Consistently, functional assays using the virus particles pseudotyped (Vpp) of SARS-CoV2-S demonstrated that tannic acid suppressed viral entry into cells. Thus, our results demonstrate that tannic acid has high potential of developing anti-COVID-19 therapeutics as a potent dual inhibitor of two independent enzymes essential for SARS-CoV-2 infection.