The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
Carrow I. Wells, Hassan Al‐Ali, David M. Andrews, Christopher R. M. Asquith, Alison Donnelly Axtman, Ivan Đikić, Daniel V. Ebner, Peter Ettmayer, Christian Fischer, Mathias Ugelstad Frederiksen, Robert E. Futrell, Nathanael S. Gray, Stephanie B. Hatch, Stefan Knapp, Ulrich Lücking, Michel Michaelides, Caitlin E. Mills, Susanne Müller, Dafydd R. Owen, Alfredo Picado · International Journal of Molecular Sciences · 2021
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.