Formulation, Optimization and Evaluation of Multiple Emulsion of Atorvastatin
S Sivapriya, Daisy P.A, Praveen Raj R · International Journal of Pharmaceutical Sciences Review and Research · 2020
Multiple emulsions are often stabilized using a combination of hydrophilic and hydrophobic surfactants.The ratio of these surfactants is important in achieving stable multiple emulsions.Atorvastatin was selected as a model drug to study the potential of multiple emulsions to improve bioavailability with the hypothesis that improvement of drug release profile will reflect the enhancement of bioavailability of the drug.The objective of this study was to prepare multiple emulsion of Atorvastatin by two step emulsification using non-ionic surfactants, and evaluate for stability, percentage drug entrapment, In-Vitro & Ex-Vivo drug release.The different variables like, rpm, concentration of surfactants and ratio of aqueous and oil phase were optimized to get the stable emulsion with high drug release and less particle size.The study concluded that stable multiple emulsion with high drug release can be prepared by two step emulsification method using Span80 as primary emulsifier at 30:70 phase volume ratio of internal phase: external phase with optimized speed of stirring at 3000 r/min for 15 mins for primary emulsification.The optimized formula were used for the preparation of multiple emulsion with the optimum drug release characteristics.