Drug Development: In Silico, In Vivo, and System Biology Approach
Prem Prakash Kushwaha, Rebati Malik, Shiv Govind Rawat, Atul Kumar Singh, Shashank Kumar · Apple Academic Press eBooks · 2020
Drug development comprises a series of steps to uncover the various properties of a single compound. Various drug development programs have been initiated due to the failure of drugs in clinical trials. Recent approaches encompass various sequential ways to overcome the cost and time consumption in drug discovery. In silico approaches includes the screening of compounds, identification of suitable pharmacokinetic activity and their behavior (inhibitory/inducible) against the target. Compounds pass from the in silico barriers ready for the testing for various assays and in animal models. Later, successive lead drugs entered in the clinical trials. In this chapter, we reviewed the different software and databases requires for the in silico studies and different approaches involved in the drug discovery.