Design and screening of SGK1, Src dual inhibitors using pharmacophore models, molecular docking, and molecular dynamics simulation
Chuance Sun, Lichuan Zhang, Chenglong Gao, Haoran Zhang, Rilei Yu, Congmin Kang · New Journal of Chemistry · 2020
Serum and glucocorticoid-regulated protein kinase 1 that can promote the growth of tumor cells is highly expressed in many tumors. Sarcoma gene plays an important role in the pathogenesis of cancer and is an important kinase in tumor cell expression pathways.