The Guide to PHARMACOLOGY druggable genome coverage
Christopher Southan, Elena Faccenda, Joanna L Sharman, Simon D Harding, Adam J Pawson, Jamie A. Davies · Proceedings for Annual Meeting of The Japanese Pharmacological Society · 2018
Background: The term druggable genome was coined in 2002 for the estimate of 10% of the human proteome likely to bind small molecules with lead-like chemical properties and sufficient binding affinity for activity modulation. A number of databases now provide protein target lists based largely on chemistry-to-protein mappings extracted from the literature. The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) contains expert curated target sets at a high stringency and updated approximately bi-monthly [1]. This work introduces the statistics of GtoPdb proteome coverage and compares this with other established sources.