Analysis of the scientific competency questions followed by the IMI OpenPHACTS consortium for the development of the semantic web-based molecular information system OPS
Khalil Azzaoui, Edgar Jacoby, Stefan Senger, Emiliano Cuadrado Rodríguez, Mabel Loza, Barbara Zdrazil, Marta Pinto, Antony John Williams, Victor de la Torre, Jordi Mestres, Olivier Taboureau, Matthias Rarey, Gerhard Franz Ecker · 2013
Molecular information systems play an important role in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. Herein we outline the scientific requirements followed by the IMI Open PHACTS consortium for the design of the OPS information system built on the integration of compound-target-pathway-disease/phenotype data. Typical scientific competency questions provided by the consortium members will be analyzed based on the underlying data concepts and data associations needed to answer the questions. Publicly available data sources will be listed and the need and potential of semantic web-based technology will be presented.