10.51847/Q3eGByl
Keri Lestari, Trully Deti Rose Sitorus, Instiaty Instiaty, Sandra Megantara, Jutti Levita · Time to knit · 2000
Researches on drugs to be used for COVID-19 therapy are still challenging. SARS-CoV-2 uses the angiotensin-converting enzyme (ACE2) receptor to enter the human body. The S (spike) protein structure of SARS-CoV-2 interacts with the active site of ACE2 receptor, defined as the peptidase domain, which consists of Gln24, Asp30, His34, Tyr41, Gln42, Met82, Lys353, Arg357. This work studied the interaction of three quinoline-based antimalarial drugs with the peptidase domain of ACE2 receptor. The X-ra