Statistical Approach to Modelling of Activity of Phenol's and its Derivatives against L1210 Leukaemia cells
Sameer Dixit, Arun K. Sikarwar · Asian Journal of Research in Chemistry · 2020
A Quantitative Structure-Property relationship (QSPR) model was developed for prediction of Activity of Phenol's and its congeners against L1210 Leukaemia cells. Murine cell lines such as P388 leukemia, L1210 leukemia, and B16 melanoma, dominated the early years of cancer cell testing both in culture and in mice. In this study we have attempted to develop a multiple linear regression (MLR) model with high accuracy and precision. For this first we prepare several models and then validate them by statistical parameters like Q Factor, PE, PSE, SPRESS etc. and proposed a model which has better prediction power to prediction of Activity against L1210 Leukaemia cells.