Application progress of drug metabolism model in the innovative drug research
Wang Minglei · Zhongguo jiceng yiyao · 2018
To review the current status of drug metabolism model.To retrieve, analyze and summarize the relevant literatures of the database.There are many kinds of drug metabolism models and mechanisms.Every model has its own advantages and disadvantages.The researchers should use in vitro experiments based on the purpose of the study and the existing laboratory conditions.If the compounds have good metabolic properties in vitro, they can be further tested in vivo to make a reasonable and accurate prediction for drug metabolic properties. Key words: Drug research; Drug metabolism; Models in vitro; Models in vivo