Expression of Fascin on human early-stage non-small-cell lung cancer tissue and its clinical characteristics
Tiepeng Han, Lei Yang, Jinjing Tan, Meng Gu, Yue Wang, Zitong Wang, Wentao Yue · Chinese Journal of Thoracic and Cardiovaescular Surgery · 2017
Objective To investigate the expression of Fascin in early-stage NSCLC, evaluate the relevance between Fascin expression level and prognosis. Methods The immunohistochemistry method was used to assess the expression of Fascin in 111 lung cancer FFPE tissues with stage Ⅰ and Ⅱ NSCLC. The relationship between Fascin expression and the clinicopathological characteristics was analyzed. The prognostic significance of Fascin expression was evaluated with Kaplan-Meier survival analysis. Results In the early-stage of NSCLC, the positive rate of Fascin expression was 64.8%, no expression in the paracarcinoma tissue. The positive rate of squamous cell carcinoma was 78.7% and was significantly higher than that in adenocarcinoma 48.0%(P<0.01). Whether in squamous cell carcinoma or adenocarcinoma group, the expression of Fascin was correlated significantly with lymph node metastasis tumor stages and DFS(P<0.05). And the positive expression of Fascin was an independent risk factor of poor prognosis for patient with NSCLC. Conclusion Fascin is expected to be a biomarker for the prognosis of patients with early-stage NSCLC. Key words: Fascin; Carcinoma, non-small-cell lung; Immunohistochemistry; Prognosis