Personalized medicine:current status, challenges and strategies
Hong‐Hao Zhou, Wei Zhang · Zhonghua jianyan yixue zazhi · 2011
Modern pharmacogenomics demonstrates that genetic polymorphisms account for the most important factor of adverse drug reactions and interindividual variations of drug therapy. Personalized medicine aims to choose the appropriate drugs and dosage for increasing the efficacy and safety with minimal adverse effects based on the patients' genotypes. This article introduce the progresses in pharmacogenomics in China, discusse many factors that influence the application of personalized medicine from bench to bedside, and highlighted the challenges and further development of this field in the future. Key words: Pharmacogenomics; Genetic markers; Polymorphism,genetic; Genotype