Rational design of novel coumarins: A potential trend for antioxidants in cosmetics
Apilak Worachartcheewan, Veda Prachayasittikul, Supaluk Prachayasittikul, Visanu Tantivit, Chareef Yeeyahya, Virapong Prachayasittikul · PubMed · 2019
rational design of an additional set of 69 structurally modified coumarins with improved antioxidant activity. Finally, a set of 9 promising newly design compounds were highlighted for further development. Structure-activity analysis also revealed key features required for potent activity which would be useful for guiding the future rational design. In overview, our findings demonstrated that QSAR modeling could possibly be a facilitating tool to enhance successful development of bioactive compounds for health and cosmetic applications.