RNA-protein correlation of liver toxicity markers in HepaRG cells
Albert Braeuning, Almut Mentz, Felix F. Schmidt, Stefan P. Albaum, Hannes Planatscher, Jörn Kalinowski, Thomas O Joos, Oliver Poetz, Dajana Lichtenstein · PubMed · 2019
, was very similar between the mRNA and protein levels. Thus, this study does not only characterize the response of human liver cells to 30 different pesticides but also demonstrates that hepatotoxicity testing in human HepaRG cells yields well comparable results at the mRNA and protein levels. Furthermore, robust hepatotoxicity marker genes and proteins were identified in HepaRG cells.