A review on : Computer Aided Drug Design
Dharampreet singh, Ramanjeet Kaur · Journal of Emerging Technologies and Innovative Research · 2020
Computational approaches in drug design, discovery and admiration. Generally, drug discovery takes a long duration of time period about 12 year and billon of capital. It includes the creating of new molecules, docking molecules to target protein, analysing molecular interaction, estimating binding strength and drug properties. Computer Aided Drug Designing (CADD) is cost effective and free of some biological trials. It mainly consists of two types of drug design that is structure -based drug design and ligand-based drug design. Through it we can know about the drug receptor interaction. Structure Based Drug Design includes binding site identification, docking and stocking, virtual screening, compound selection, lead optimization. Ligand Based Drug Design includes quantitative structure activity relationship, pharmacologic modelling and steps followed as structure- based drug design. As we can see CADD help to recognize suitable characteristics of a drug and its compatibility to get an easy hand in pre- clinical trials.