SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL SCREENING OF NOVEL TRANSITION METAL COMPLEXES OF MANNICH BASE 7-((DIPHENYLAMINO) (4-CHLOROPHENYL) METHYL) QUINOLIN-8-OL
Mangesh S. Tihile, G. N. Chaudhari · Journal of Emerging Technologies and Innovative Research · 2020
A novel ligand mannich base 7-((diphenylamino) (4-chlorophenyl) methyl) quinolin-8-ol was synthesized by condensation method. The transition metal ion Co (II), Mn (II), Cu (II), Ni (II) and Zn (II) acetate salts were incorporated with Mannich base to form metal-ligand complexes. The novel synthesized ligand and their metal-ligand complexes have been elucidated by H1 NMR, IR and mass spectral data. The prepared compound (Ligand) and metal ion complexes were screened against the Gram +Ve and Gram –Ve bacteria. Almost all complexes showed good antibacterial activity. In particular, Copper, Nickel and Zinc metal ion complexes showed best antibacterial activity.