THE DEVELOPMENT OF TOXICOLOGICAL TOLERANCE TO ISONIAZID IN EXPERIMENT
Konstantin Usov, Т. А. Гуськова, G. G. Jushkov, А. В. Машанов, V. V. Igumenshcheva · Toxicological Review · 2017
Results of experimental studies are reported that made it possible to establish decrease in sensitivity and the development of toxicological tolerance (addiction) to the anti-tuberculosis drug “Isoniazid” repeatedly administered to laboratory animals in toxic doses and to determine growth rate of the toxicological tolerance development, maximum and average life expectancy, severity of seizures .