Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)
Nadia Gamal Zaki, Walaa H. Mahmoud, Ahmed Mahmoud El Kerdawy, Abanoub Mosaad Abdallah, Gehad Genidy Mohamed · Egyptian Journal of Chemistry · 2019
Reaction of cocaine (Cn) with Mn(II) and Cu(II) chloride salts afforded complexes of the [M(Cn)Cl(OH2)3]Cl type which were structurally characterized by elemental analysis, conductance measurements, spectroscopic methods and mass spectroscopy. Their thermal properties were studied. The in vitro antitumor activity of the newly synthesized complexes was investigated by MTT assay on MCF-7 and HepG-2 cell lines. Both complexes exhibited promising cytotoxic activity on both cell lines with high safety on normal human cells. Their antifungal activity against Aspergillus fumigatus and Candida albicans and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium and Escherichia coli were also included.