Validation of C-Reactive protein and CURB-65 in the first hospital admission community acquired-pneumonia patient as a predictor of 30 days mortality
Borries Foresto Buharman · 2018
Background : the British Thoracic Society uses CURB-65 scoring system to evaluate the severity of pneumonia. On the other hand, some earlier researches indicated that discrimination score of CURB-65 performance to predict mortality is still below of expectations. Therefore, another prognostic factor as an added value is mandatory. In some earlier researches C Reactive Protein has a role as an independent factor to predict mortality in community acquired-pneumonia. Objective : To evaluate the role of C Reactive Protein together with CURB-65 score to predict 30-days mortality in hospitalized community acquired-pneumonia patient. Method : This is a prospective cohort study of hospitalized community acquired-pneumonia patients in Cipto Mangunkusumo Hospital, Jakarta, Indonesia. This study has been conducted from October–November 2017. The Outcome measure of the study is that mortality occurs in 30 days. Performance of CURB-65 score was evaluated before and after addition of C Reactive Protein. Results: The number of mortality in this research is 37%. Performance discrimination of CURB-65 score was shown by ROC curve, the AUC is 70,1%(CI95% 0,62 – 0,77). After addition of C Reactive Protein based of cut off (≥48,5 mg/L), the AUC score improved 88,0%(CI95% 0,83 – 0,92). Conclusion: C Reactive Protein has a role to CURB-65 score to predict 30 days mortality in hospitalized community acquired-pneumonia patient. Key Words: Hospitalized community acquired-pneumonia patient, 30 days mortality, CURB-65 score, C Reactive Protein