Synthesis of a New Antihyperlipidaemic Agent-Simvastatin
LI Chuan-mao · 2005
Simvastatin is a new antihyperlipidaemic agent. It can be synthesized with the material of lovastatin, hydroxy protecting agent of trimethylchlorosilane, and t-butyl lithium instead of pyrrole lithium. The total yield is about 78%.The structure is identified by UV,IR,MS,NMR spectrums.This method is very easy and the cost is very low, but the yield is high. Most of organic solvents can be recovered in order to be used next time. So this method will have perfect industrialization foreground.