In Silico Homology Modeling of Presenilin 2-Therapeutic Target for Alzheimer's disease
Sowmya Hari, S. Akilashree · Research Journal of Pharmacy and Technology · 2019
Alzheimer's disease is a neurodegenerative disorder which is caused by several mutations in causative proteins like Amyloid Precursor Protein (APP), Presenilin1 (PSEN1), and Presenilin2 (PSEN2). Mutations in presenilin 2 lead to the overproduction of amyloid beta peptide which gets accumulated in the brain and causes neuron death.