Abstract OR-19: Integrative Approach on Nucleosome Complexes Modeling
Grigoriy A. Armeev, Anna R. Panchenko, Alexey К. Shaytan · International Journal of Biomedicine · 2019
Background: Nucleosomes are the key structural elements of chromatin in all higher organisms. While X-ray crystallography studies of nucleosomes have consistently yielded similar atomistic structures, many biophysical and biochemical techniques suggest that nucleosomes and nucleosome complexes exhibit substantial conformational polymorphism, which is functionally important. The interpretation of such experimental data with such sufficient details is often a tedious task, thus a set of molecular modeling tools is required.