The Role of Raman Spectroscopy in Differentiating Grades of Dysplasia in Barrett's Oesophagus: Is It Currently Good Enough?
Emma Upchurch, Martin Isabelle, Lloyd Gr, Catherine A. Kendall, Nicholas Stone, Hugh Barr · International Journal of Experimental Spectroscopic Techniques · 2018
Many cancers, including oesophageal adenocarcinoma, develop from tissue that becomes increasingly dysplastic, however, these changes are often difficult to identify by histopathological changes. If these changes can be diagnosed at an early stage, this has the potential to improve management, and outcome, for these patients. Raman spectroscopy has the potential to be such a tool, with the ability to diagnose pathological changes through the elucidation of spectral biomarkers that are associated with biochemical changes that are the result of disease progression.