Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions
Mei Xiao, Hongsong Yang, Suzane M. Klein, Christian Mbangha Muenyi, William Stone, Yu Jiang · Letters in Organic Chemistry · 2008
A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give tbutyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration. Keywords: Anticancer drug, NCX 4040, design, synthesis, mild conditions, LNCaP cancer cell lines, prostate cancer