Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates
Michael Palucki, John D. Higgins, Elizabeth C. Kwong, Allen C. Templeton · Journal of Medicinal Chemistry · 2010
ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTStrategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug CandidatesMichael Palucki*, John D. Higgins*, Elizabeth Kwong, and Allen C. TempletonView Author Information Basic Pharmaceutical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, Pennsylvania 19486*To whom correspondence should be addressed. For M.P.: phone, 215-652-7016; fax, 215-652-7310; e-mail, [email protected]. For J.D.H.: phone, 215-652-3669; fax, 215-652-7310; e-mail, [email protected]Cite this: J. Med. Chem. 2010, 53, 16, 5897–5905Publication Date (Web):June 8, 2010Publication History Received26 February 2010Published online8 June 2010Published inissue 26 August 2010https://pubs.acs.org/doi/10.1021/jm1002638https://doi.org/10.1021/jm1002638review-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views4330Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Drug discovery,Pharmaceuticals,Phases of matter,Solubility Get e-Alerts