Systems Biology Brings New Dimensions for Structure-Based Drug Design
Jianfeng Pei, Ning Yin, Xiaomin Ma, Luhua Lai · Journal of the American Chemical Society · 2014
In this Perspective, we focus on new, systems-centric views of structure-based drug design (SBDD) that we believe will impact future drug discovery research and development. We will first discuss new ways to identify drug targets based on systems intervention analysis, and then we will introduce emerging SBDD methods driven by advancements in systems biology.