Computational Method for Prediction of White Thrombus Formation with Consideration of Platelet Aggregation and Separation
Yingming Yi, Masaaki TAMAGAWA · Keisan Rikigaku Koenkai koen ronbunshu/Keisan Rikigaku Kouenkai kouen rombunshuu · 2018
Platelet aggregation and separation are important processes in thrombus formation. In our previous investigations, dissipative particle dynamics(DPD) has been used to simulate thrombus formation on orifice flow. In DPD, particle means platelet. However, the number of particles is vast when platelet concentration is the same as the blood. In this investigation, virtual particle model is used to decrease the number of particles. In our virtual particle model, several platelets are considered to be one virtual particle. In order to focus on the aggregation number in cases of different numbers of virtual particles, new variable of relative aggregation number is used. It is found that the relative aggregation numbers are almost the same although numbers of particles are different. It means that the probabilities of platelet aggregation are almost the same. So it is concluded that the aggregation number can be computed by using the model of virtual particle.