3D QSAR STUDY ON ALPHA KETO AMIDE DERIVATIVES AS GP120-CD4 INHIBITORS
Vinayak D. More, Prafulla Balkrishna Choudhari, Rakesh Pandit Dhavale, Swapnil D. Jadhav, Manish Sudesh Bhatia · International Journal of Pharmaceutical Sciences and Drug Research · 2012
The present communication deals with 3D QDAR analysis on series of Alpha keto amide derivatives some for the designing of new GP120-CD4 inhibitors with anti HIV activity. The four different QSAR models are generated using data set of 32 molecules as gp120-CD4 inhibitors from literature studies. The 3D QSAR result gives insights for understanding of the relationship between structural features of substituted alpha keto amide derivatives and their activities which should be useful to design newer potential anti-HIV agents.