An efficient deep neural network for classification in esophageal cancer histopathological images (CNN+LSTM)
Jing Ge, Ying Xie, Di Wang · 2019
Esophageal cancer is one of the leading causes of mortality worldwide. Early diagnostics are imperative of improving the chances of correct treatment and survival. Pathology examination requires time consuming scanning while often leads to a disagreement among pathologists. The computer-aided diagnosis systems are critical to improve the diagnostic efficiency and reduce the subjectivity and error of human. In this paper, a deep learning–based approach is proposed to classify the H&E stained histopathological images of esophageal cancer. The histopathological images are firstly normalized to correct the color variations during slide preparation. Then one image patch is cut into five pieces and gets five corresponded features via convolutional neural networks (CNNs). Subsequently, the five features of one image patch are fed into the Long Short-Term Memory (LSTM) model for further feature extraction and integrated as one for the last classification. The experiment results have demonstrated the proposed approach is effective to classify the esophageal histopathological images with the accuracy of 84.5% which outperforming 10 percent than GoogleNet.