Identifying Novel Candidates for Re-Purposing as Potential Therapeutic Agents for Alzheimer’s disease
Clive G. Ballard, Byron Creese, A Gatt, Patrick J. Doherty, Paul T. Francis, D Whitfield, Anne Corbett, J Corcoran, Diane P. Hanger, Sandrine Thuret, Richard Killick, Gareth Haydn Williams · bioRxiv (Cold Spring Harbor Laboratory) · 2019
Abstract The current paper describes the identification of novel candidate compounds for repositioning as treatments for Alzheimer’s disease (AD) from the CMAP library. Candidate compounds were identified based on inverse correlation with transcriptome signatures developed from meta-analyses of Alzheimer RNA expression studies using the SPIED platform. The 78 compounds with a significant inverse correlation were taken forward into an in vitro programme using 6 well validated screening assays relevant to potential treatment targets in AD. Nineteen pf the compounds were hits in at least 2 of these assays. A description of each of these compounds is presented.