Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays
Shenzhen Huang, Xiang Wang, Guifeng Lin, Jie Cheng, Xiuli Chen, Weining Sun, Rong Xiang, Yamei Yu, Linli Li, Shengyong Yang · RSC Advances · 2019
= 8.8 μM). In intact HeLa cells, this compound showed a protective effect against DNA damage. Compound 11 is a good lead compound for the further development of drugs against disorders caused by DNA damage.