Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
Andrew Michael Beekman, Marco M. D. Cominetti, Samuel J. Walpole, Saurabh Prabhu, Maria Anne O'Connell, Jesús Angulo, Mark Searcey · Chemical Science · 2019
DMX-selective agents exist in the literature. Preliminary biological studies show that 20% of the compounds identified have cellular activity and activate downstream pathways associated with p53 activation.