042. The "ABC-System": Automation, Barcodes, and Chaos
J.H. Bouman, K.J. van der Eijk, E.J. van der Brink, G.J. Noordergraaf, Jan Meulenbelt, T.J.F. Savelk · Prehospital and Disaster Medicine · 1995
Introduction: Endotoxemia originating from the gut is a common pathophysiological process following hemorrhagic shock.Objective: The goal of the current experiments was to determine whether Chinese traditional medicine rhubarb could decrease intestinal permeability and prevent endotoxin within the intestinal lumen from being absorbed.Methods: The rhubarb (50 mg/kg) was administered to the experimental rats via oral-gastric tubes each time before shock was induced and at 4, and 12 hours after shock resuscitation.Results: The plasma concentration of endotoxin did not change significantly in the sham-shocked rats following the operation.However, it increased significantly 4 hours following resuscitation in shocked rats (p <0.01) .The rats treated with the rhubarb exhibited a lower degree of endotoxemia than did the shocked rats and the placebo-treated rats (p <0.01).Histopathological damage of the jejunem of the rhubarbtreated rats was less than that of the shocked rats and of the placebo treated rats.Conclusions: Rhubarb can protect the gut barrier from hemorrhagic shoch.