Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 2
Ahmed F. Abdel‐Magid, Jaan A. Pesti, Rajappa Vaidyanathan · ACS symposium series · 2016
Pevonedistat (MLN-4924, TAK-924) is a first-in-class inhibitor of Nedd-8 activating enzyme (NAE) currently undergoing clinical evaluation in oncology. This chapter will discuss the identification of pevonedistat and describe the synthetic routes undertaken by discovery chemists to provide material for pre-clinical studies.