ChemInform Abstract: Discovery of Novel Hepatoselective HMG‐CoA Reductase Inhibitors for Treating Hypercholesterolemia: A Bench‐to‐Bedside Case Study on Tissue Selective Drug Distribution.
Jeffrey A. Pfefferkorn, et al. et al. · ChemInform · 2012
Abstract Replacement of the pyrrole core of atorvastatin with five‐membered heterocycles and further improvement of the hepatoselectivity of the resulting pyrazole‐based HMG‐CoA inhibitor candidate lead to imidazole‐based HMG‐CoA reductase inhibitors such as (I).