Homology Modelling and Evaluation of the CannabinoidReceptor Type 2
Fatima I. Sapundzhi, Tatyana A. Dzimbova, Nevena Pencheva, Peter Milanov · Proceedings of the 35th European Peptide Symposium · 2018
The human cannabinoid receptor type 2 (CB2) is linked to a variety of immune functional events which are found primarily in brain and tissues of immune and hematopoietic systems like spleen, tonsil, and thymus. In the absence of crystal structure of CB2 receptor, 3D homology patterns with different templates are built [1,2]. The aims of the present study are: (1) to choose within the recently published crystallographic structures templates for homology modelling of the CB2 receptor; (2) to evaluate the models with different computational tools; (3) to precise the most reliable model on the basis of the correlation between data from molecular docking and the values of the biological activity of the cannabinoid ligands.