Enabling Privacy-Preserving Sharing of Genomic Data for GWASs in Decentralized Networks
Yanjun Zhang, Xin Zhao, Xue Li, Mingyang Zhong, Caitlin Curtis, Chen Chen · 2019
The human genome can reveal sensitive information and is potentially re-identifiable, which raises privacy and security concerns about sharing such data on wide scales. In this work, we propose a preventive approach for privacy-preserving sharing of genomic data in decentralized networks for Genome-wide association studies (GWASs), which have been widely used in discovering the association between genotypes and phenotypes. The key components of this work are: a decentralized secure network, with a privacy- preserving sharing protocol, and a gene fragmentation framework that is trainable in an end-to-end manner. Our experiments on real datasets show the effectiveness of our privacy-preserving approaches as well as significant improvements in efficiency when compared with recent, related algorithms.